Beilstein J. Org. Chem.2015,11, 730–738, doi:10.3762/bjoc.11.83
according to well-established protocols [65]. Consequently, we adopted the Sharpless–Fokin modification for the Huisgen azide–alkyne cycloaddition [66] to achieve the final immobilization of the modified imidazolidin-4-one onto the hyperbranchedpolymer and on the G1 dendron [65]. The progress of the
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Graphical Abstract
Scheme 1:
Synthesis of hyperbranched polyglycerol-supported and G1 dendronized imidazolidin-4-ones 4a–c and 8...
Beilstein J. Org. Chem.2014,10, 2696–2703, doi:10.3762/bjoc.10.284
; hyperbranchedpolymer; multifunctionality; polymer nanocarrier; Introduction
In recent years, many nanostructured materials (such as polymeric micelles) used as pharmaceutical nanocarriers have been applied in different fields of biomedicine for controlled release, diagnostics, imaging, treatment and
very regular (Figure 2B and C). Furthermore, as seen in Figure 2B and C, larger aggregates were formed due to the attachment of the HBPCSi segments and β-CD moieties. Large second aggregates from hyperbranched, polymer-based copolymers were also observed by Hong et al. [25]. However, the irregular
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Graphical Abstract
Scheme 1:
Schematic representation of the details for the construction of a multifunctional nanocarrier used ...